EDNRB/Endothelin R Type B Antibody - BSA Free

Novus Biologicals | Catalog # NLS57

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Canine, Goat, Hamster, Monkey, Primate, Rabbit

Predicted:

Opossum (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all EDNRB/Endothelin R Type B Primary Antibodies »

Product Specifications

Immunogen

Synthetic 19 amino acid peptide from C-terminus of human EDNRB/Endothelin R Type B.

Epitope

C-Terminus

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%).

Specificity

Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for EDNRB/Endothelin R Type B Antibody - BSA Free

Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS57]

Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS57]

Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS57] - Analysis of anti-EDNRB antibody with human vessels.

Applications for EDNRB/Endothelin R Type B Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

8 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: EDNRB/Endothelin R Type B

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Long Name

Endothelin Receptor Type B

Alternate Names

EDNRB, ET-B, ETRB

Entrez Gene IDs

1910 (Human)

Gene Symbol

EDNRB

Additional EDNRB/Endothelin R Type B Products

Product Documents for EDNRB/Endothelin R Type B Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for EDNRB/Endothelin R Type B Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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