Catalog Number: 3378
Alternate Names: Ethylisopropyl amiloride
Chemical Name: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
Biological Activity
TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).
Technical Data
  • M.Wt:
    299.76
  • Formula:
    C11H18ClN7O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1154-25-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells.
    Horinouchi et al.
    J.Pharm.Sci., 2008;107:456
  2. Inhibition of TRPP3 channel by amiloride and analogs.
    Dai et al.
    Mol.Pharmacol., 2007;72:1576

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