Chemical Name: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
Biological ActivityTRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells.
Horinouchi et al.
Inhibition of TRPP3 channel by amil. and analogs.
Dai et al.
Citations for EIPA
The citations listed below are publications that use Tocris products. Selected citations for EIPA include:
2 Citations: Showing 1 - 2
NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages.
Authors: Neubert Et al.
PloS Biol 2020;18
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Authors: Knudsen Et al.
Cell Metab 2019;29:430
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