4 results for "TRPP Channel Blockers" in Products
TRPP Channel Blockers
The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. The TRPP channels are divided into two structurally distinct groups, polycystic kidney disease 1-like (PKD1-like) and polycystic kidney disease 2-like (PKD2-like). Members of the PKD1-like group in mammals include PKD1 (reclassified as TRPP1), PDKREJ, PKD1L1, PKD1L2 and PKD1L3. The PKD2-like members include PKD2; PKD2L1; and PKD2L2, which have ...
Na+ channel blocker; also I2 imidazoline ligand
| Chemical Name: | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride |
| Purity: | ≥98% |
Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)
| Alternate Names: | Ethylisopropyl amiloride |
| Chemical Name: | 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide |
| Purity: | ≥98% |
NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative
| Chemical Name: | N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride |
| Purity: | ≥98% |
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
| Chemical Name: | 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt |
| Purity: | ≥98% |
