Biological ActivityHigh affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions.
Murza et al.
Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.
Yang et al.
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