EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted

Novus Biologicals | Catalog # NBP2-44535

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 8D6

Format

IHC-Prediluted
View all EMMPRIN/CD147 Primary Antibodies »

Product Specifications

Immunogen

Human T cell line Molt 13

Localization

Cell surface

Specificity

This monoclonal antibody recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.

Scientific Data Images for EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted [NBP2-44535]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted [NBP2-44535]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted [NBP2-44535] - Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with CD147 Monoclonal Antibody (8D6).
EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted Western Blot: EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted [NBP2-44535] -

Western Blot: EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted [NBP2-44535] -

Western Blot Analysis of HepG2 lysate using EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted.

Applications for EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted

Application
Recommended Usage

Immunohistochemistry-Paraffin

0.5 - 1.0 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Format

IHC-Prediluted

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: EMMPRIN/CD147

CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.

Long Name

Extracellular Matrix Metalloproteinase Inducer

Alternate Names

Basigin, BSG, CD147

Gene Symbol

BSG

Additional EMMPRIN/CD147 Products

Product Documents for EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted

Certificate of Analysis

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Product Specific Notices for EMMPRIN/CD147 Antibody (8D6) - IHC-Prediluted

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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