Ex 26
Chemical Name: 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid
Purity: ≥98%
Biological Activity
Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification.
Teijaro et al.
Proc.Natl.Acad.Sci.U.S.A., 2016;113:1351 -
Sphingosine 1-phosphate receptor 1 (S1P1) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P1 antagonist.
Cahalan et al.
Mol.Pharmacol., 2013;83:316 -
S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo.
Kleinwort et al.
Int.J.Mol.Sci., 2018;19:E391
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