High affinity glucagon-like peptide 1 (GLP-1) receptor agonist (K
= 136 pM); originally isolated from
venom. Potently induces cAMP formation without stimulating amylase release in pancreatic acini. Potentiates glucose-induced insulin secretion in isolated rat islets. Protects against glutamate-induced neurotoxicity.
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All Tocris products are intended for laboratory research use only.
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom.
Eng et al.
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells.
Goke et al.
Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.
Thorens et al.
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
Perry et al.
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