Potent and selective noncompetitive AT1
receptor antagonist (IC50
= 37 nM). Reduces blood pressure in a rat model. Active metabolite of losartan potassium
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Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
Wong et al.