EXP 3174

Key Product Details

Product Description

EXP 3174 is a potent and selective noncompetitive AT₁ receptor antagonist (IC₅₀ = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).

Product Specifications for EXP 3174

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EXP 3174

The following data is based on the product molecular weight 436.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.14 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wong Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 1990 PMID: 2213556

Product Documents for EXP 3174