Chemical Name: 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Biological ActivityEXP 3174 is a potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
Wong et al.
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