Factor XIIIa Antibody (AC-1A1)

Novus Biologicals | Catalog # NB100-696

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # AC-1A1
View all F13A1 Primary Antibodies »

Product Specifications

Immunogen

BALB/C mice were injected with recombinant human protein corresponding to A-subunit of coagulation Factor XIII.

Reactivity Notes

Not yet tested in other species.

Localization

Cytoplasmic and nuclear

Marker

Dendritic Cell Marker

Specificity

This is specific to 160 kDa protein known as Factor XIIIA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Factor XIIIa Antibody (AC-1A1)

Immunohistochemistry-Paraffin: Factor XIIIa Antibody (AC-1A1) [NB100-696]

Immunohistochemistry-Paraffin: Factor XIIIa Antibody (AC-1A1) [NB100-696]

Immunohistochemistry-Paraffin: Factor XIIIa Antibody (AC-1A1) [NB100-696] - Formalin fixed paraffin embedded human placenta stained with Factor XIII-A antibody (NB100-696).

Applications for Factor XIIIa Antibody (AC-1A1)

Application
Recommended Usage

Immunohistochemistry

1:25-1:50

Immunohistochemistry-Paraffin

1:25-1:50
Application Notes
IHC-P: recommended pretreatment of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS (pH 7.4), 0.2% BSA, Tween-20

Preservative

0.05% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: F13A1

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Long Name

Coagulation Factor XIII, A1 Polypeptide

Alternate Names

F13A, FSF, A Subunit

Entrez Gene IDs

2162 (Human)

Gene Symbol

F13A1

UniProt

P00488 (Human)

Additional F13A1 Products

Product Documents for Factor XIIIa Antibody (AC-1A1)

Certificate of Analysis

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Product Specific Notices for Factor XIIIa Antibody (AC-1A1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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