Fenobam

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Fenobam | CAS No. 57653-26-6 | Group I mGluR Modulators
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Description: Potent and selective mGlu5 negative allosteric modulator (NAM)

Chemical Name: N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.

Technical Data

M.Wt:
266.69
Formula:
C11H11N4O2Cl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
57653-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Fenobam

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