Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Biological ActivityCyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
Kaur et al.
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Ambrosini et al.
Cancer Res., 2008;68:2312
Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
Losiewicz et al.
Citation for Flavopiridol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Flavopiridol hydrochloride include:
1 Citation: Showing 1 - 1
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
Authors: Stork Et al.
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