Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1
phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50
= 25 - 160 nM) in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
Kaur et al.
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Ambrosini et al.
Cancer Res., 2008;68:2312
Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
Losiewicz et al.