Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Biological ActivityCyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
Kaur et al.
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Ambrosini et al.
Cancer Res., 2008;68:2312
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
Losiewicz et al.
Citation for Flavopiridol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Flavopiridol hydrochloride include:
1 Citation: Showing 1 - 1
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
Authors: Stork Et al.
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