Catalog Number: 3094
Alternate Names: L 86-8275
Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Biological Activity
Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
Technical Data
  • M.Wt:
    438.3
  • Formula:
    C21H20ClNO5.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    131740-09-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
    Kaur et al.
    J.Natl.Cancer.Inst., 1992;84:1736
  2. The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
    Ambrosini et al.
    Cancer Res., 2008;68:2312
  3. Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
    Losiewicz et al.
    Biochem.Biophys.Res.Comm., 1994;201:589

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