Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Biological ActivityFlavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275.
Kaur et al.
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Ambrosini et al.
Cancer Res., 2008;68:2312
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275.
Losiewicz et al.
Citation for Flavopiridol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Flavopiridol hydrochloride include:
1 Citation: Showing 1 - 1
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
Authors: Stork Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Flavopiridol hydrochloride
There are currently no reviews for this product. Be the first to review Flavopiridol hydrochloride and earn rewards!
Have you used Flavopiridol hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image