FMRP Antibody

Novus Biologicals | Catalog # NBP1-51944

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all FMRP Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NPNKPATKDTFHKIK corresponding to internal region according to NP_002015.1.

Epitope

C-NPNKPATKDTFHKIK

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for FMRP Antibody

Western Blot: FMRP Antibody [NBP1-51944]

Western Blot: FMRP Antibody [NBP1-51944]

Western Blot: FMRP Antibody [NBP1-51944] - NBP1-51944 (0.3ug/ml) staining of Kelly lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for FMRP Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 70 kDa band observed in lysates of HeLa, Jurkat and Kelly (calculated MW of 71.2 kDa band according to NP_002015.1). IHC: An anonymous customer has reported found nuclear staining in selected trophoblasts of human term placenta.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FMRP

Fragile X syndrome is the most common inherited form of mental retardation. It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein. In mammals, FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins, including two KH domains and an RGG box.The Drosophila genome contains a single gene homologous to the FXR family. dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes, like its human counterpart. dFMR1 profile of expression recapitulates that of the human FXR protein family: it is highly enriched in muscles, in central nervous system and in gonads. In the larval brain, anti-dFMR1 also recognizes mushroom bodies, a centre that mediates learning and memory. These features make the fly an ideal system to analyze the role of the FXR family and to identify genes in the FMRP pathway.

Alternate Names

FMRPFRAXAPOF, fragile X mental retardation 1, fragile X mental retardation 1 protein, MGC87458, POF1, premature ovarian failure 1, Protein FMR-1

Entrez Gene IDs

2332 (Human); 24948 (Rat)

Gene Symbol

FMR1

UniProt

NP_002015.1 (Human)

Additional FMRP Products

Product Documents for FMRP Antibody

Certificate of Analysis

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Product Specific Notices for FMRP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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