Folic acid Antibody (FA2) - BSA Free

Novus Biologicals | Catalog # NB100-72976

Novus Biologicals
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Key Product Details

Species Reactivity

Non-species specific

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # FA2

Format

BSA Free
View all Folic acid Primary Antibodies »

Product Specifications

Immunogen

Derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with folic acid conjugated with BSA.

Reactivity Notes

Chemical

Specificity

This recognizes free folic acid.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Folic acid Antibody (FA2) - BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Folic acid

Folic acid and Folate (the anion form) are forms of a water-soluble B vitamin. These occur naturally in food and can also be taken as supplements. The biologically active form of folic acid is tetrahydrofolic acid (THFA), which is derived by the 2-step reduction of folate involving dihydrofolate reductase. THFA plays a key role in the transfer of 1-carbon units (such as methyl, methylene, and formyl groups) to the essential substrates involved in the synthesis of DNA, RNA, and proteins. More specifically, THFA is involved with the enzymatic reactions necessary to synthesis of purines, thymidine, and amino acids. Manifestations of folate deficiency thereafter, not surprisingly, would involve impairment of cell division, accumulation of possibly toxic metabolites such as homocysteine, and impairment of methylation reactions involved in the regulation of gene expression, thus increasing neoplastic risks. Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy when a deficiency can result in neural tube defects. In folate deficiency the bone marrow is affected as it is a site of rapid cell turnover. Large red blood cells called megaloblasts are produced, resulting in megaloblastic anemia.

Alternate Names

Folate, Tetrahydrofolate, Tetrahydrofolic acid, THFA

Additional Folic acid Products

Product Documents for Folic acid Antibody (FA2) - BSA Free

Certificate of Analysis

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Product Specific Notices for Folic acid Antibody (FA2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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