Catalog Number: 4751
Biological Activity
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
Technical Data
  • M.Wt:
    796.97
  • Formula:
    C39H60N10O8
  • Sequence:
    FSLLRY-NH2

    (Modifications: Tyr-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    245329-02-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.
    McLarty et al.
    Hypertension, 2011;58:264
  2. Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
    Chen et al.
    Neuroscience, 2011;193:440
  3. Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice.
    Andoh et al.
    J.Pharmacol.Exp.Ther., 2012;343:91
Citations:

The citations listed below are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:

4 Citations: Showing 1 - 4
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  1. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2
    Authors: Peng Et al.
    Phil. Trans. R. Soc. B 2016;371:1700
  2. A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
    Authors: White Et al.
    Cell Death Dis 2015;194:142
  3. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci 2014;55:3912
  4. PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain.
    Authors: Bao Et al.
    Mol Pain 2014;10:28

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