Biological ActivityFSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
(Modifications: Tyr-6 = C-terminal amide)
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Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.
McLarty et al.
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain.
Chen et al.
Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice.
Andoh et al.
Citations for FSLLRY-NH2
The citations listed below are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:
6 Citations: Showing 1 - 6
Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Authors: Noskovičová Et al.
Am J Physiol Lung Cell Mol Physiol 2018;314:L695
Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2
Authors: Peng Et al.
Phil. Trans. R. Soc. B 2016;371:1700
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Authors: White Et al.
Cell Death Dis 2015;194:142
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
Authors: Tripathi Et al.
Invest Ophthalmol Vis Sci 2014;55:3912
Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
Authors: Eum Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G992
PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain.
Authors: Bao Et al.
Mol Pain 2014;10:28
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