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FSLLRY-NH2

4751 6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4751/1
FSLLRY-NH2
1 Image
Description: PAR2 peptide antagonist
Product Details
Citations (6)
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Biological Activity

Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.

Technical Data

M.Wt:
796.97
Formula:
C39H60N10O8
Sequence:
FSLLRY-NH2

(Modifications: Tyr-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
245329-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FSLLRY-NH2

The citations listed below are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:

6 Citations: Showing 1 - 6

  1. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
    Authors: Noskovičová Et al.
    Am J Physiol Lung Cell Mol Physiol  2018;314:L695
  2. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2
    Authors: Peng Et al.
    Phil. Trans. R. Soc. B  2016;371:1700
  3. A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
    Authors: White Et al.
    Cell Death Dis  2015;194:142
  4. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci  2014;55:3912
  5. Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
    Authors: Eum Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;306:G992
  6. PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain.
    Authors: Bao Et al.
    Mol Pain  2014;10:28

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VersaClone cDNA Plasmids

Mouse PAR2 (NP_032000) VersaClone cDNA

RDC0167
1 Citations

Human PAR2 (NP_005233) VersaClone cDNA

RDC0166

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