Catalog Number: 4751
Biological Activity
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Tyr-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.
    McLarty et al.
    Hypertension, 2011;58:264
  2. Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
    Chen et al.
    Neuroscience, 2011;193:440
  3. Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice.
    Andoh et al.
    J.Pharmacol.Exp.Ther., 2012;343:91
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