FTBMT

Catalog # Availability Size / Price Qty
6784/25
6784/5
FTBMT | CAS No. 1358575-02-6 | Orphan 7-TM Receptor Agonists
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Description: Potent and selective GPR52 agonist; orally bioavailable and BBB permeable

Chemical Name: 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%). Selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. Suppresses methamphetamine-induced hyperlocomotion in mice. Inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
392.35
Formula:
C19H16F4N4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1358575-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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