Chemical Name: 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
Biological ActivityPotent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%). Selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. Suppresses methamphetamine-induced hyperlocomotion in mice. Inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists.
Tokumaru et al.
FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia.
Nishiyama et al.
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