High affinity and selective GPER receptor antagonist (Ki
= 20 nM) that displays no affinity for ERα
at concentrations up to 10 μ
M. Inhibits agonist-induced calcium mobilization in vitro
of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
In vivo effects of a GPR30 antagonist.
Dennis et al.
Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo.
Hutchens et al.
Am.J.Physiol.Renal Physiol., 2012;303:377
The citations listed below are publications that use Tocris products. Selected citations for G-15 include:
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