G-15
Chemical Name: (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
Purity: ≥99%
Biological Activity
G-15 is a high affinity and selective GPER receptor antagonist (Ki = 20 nM) that displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC50 of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Background References
-
Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo.
Hutchens et al.
Am.J.Physiol.Renal Physiol., 2012;303:377 -
In vivo effects of a GPR30 antagonist.
Dennis et al.
Nat.Chem.Biol., 2009;5:421 -
Activation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate.
Yue et al.
ACS Chem.Neurosci, 2019;10:4227
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for G-15
The citations listed below are publications that use Tocris products. Selected citations for G-15 include:
21 Citations: Showing 1 - 10
-
TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Authors: Cortes Et al.
Oncogene 2019;38:2910
-
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
Authors: Cortes Et al.
EMBO Rep 2019;20
-
TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
Authors: Cortes Et al.
EMBO Rep 2019;20
-
17β-E2 Regulates Glucose Metabolism and Ins. Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway.
Authors: Bian Et al.
Front Endocrinol (Lausanne) 2019;10:531
-
Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1.
Authors: Loiola Et al.
Front Endocrinol (Lausanne) 2019;10:420
-
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.
Authors: Caballero Et al.
Sci Rep 2017;7:40981
-
Divergent regulation of ER and kiss genes by 17�-OE in hypothalamic ARC versus AVPV models.
Authors: Treen Et al.
Mol.Endocrinol. 2016;30:217
-
Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.
Authors: Bugel Et al.
Toxicol Appl Pharmacol 2016;296:31
-
Modulatory Effects of Sex Steroids Progesterone and OE on Odorant Evoked Responses in Olfactory Receptor Neurons.
Authors: Kanageswaran Et al.
PLoS One 2016;11:e0159640
-
HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.
Authors: Bertrand Et al.
Mol Med Rep 2015;6:894
-
Estrogen accelerates the resolution of inflammation in macrophagic cells.
Authors: Villa Et al.
Breast Cancer Res 2015;5:15224
-
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
-
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamox. resistance through cancer-associated fibroblast-derived fibronectin and
Authors: Yuan Et al.
PLoS One 2015;17:69
-
G-protein-coupled receptor 30-mediated antiapoptotic effect of estrogen on spinal motor neurons following injury and its underlying mechanisms.
Authors: Chen Et al.
Sci Rep 2015;12:1733
-
Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30.
Authors: Carnesecchi Et al.
Int J Mol Sci 2015;10:e0120672
-
GPER mediates activation of HIF1α/VEGF signaling by estrogens.
Authors: Francesco Et al.
Cancer Res 2014;74:4053
-
Direct OE and diethylstilbestrol actions on early- versus late-stage prostate cancer cells.
Authors: Koong and Watson
Prostate 2014;74:1589
-
Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.
Authors: Sandner Et al.
Andrology 2014;2:695
-
Estrogen rapidly enhances incisional pain of ovariectomized rats primarily through the G protein-coupled estrogen receptor.
Authors: An Et al.
J Neurosci 2014;15:10479
-
2-MethoxyOE inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.
Authors: Duncan Et al.
Proc Natl Acad Sci U S A 2012;109:21034
-
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal mor. antinociception.
Authors: Liu Et al.
J Neurosci 2011;31:11836
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for G-15
There are currently no reviews for this product. Be the first to review G-15 and earn rewards!
Have you used G-15?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image