GABA-A R beta 2 Antibody - Azide Free

Novus Biologicals | Catalog # NB300-198

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Cited:

Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Human (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide Free
View all GABA-A R beta 2 Primary Antibodies »

Product Specifications

Immunogen

Fusion protein from the cytoplasmic loop of the beta 2 subunit. Accession # P63138

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 16807363).

Localization

Cell Membrane; multi pass membrane protein

Specificity

Specific for endogenous levels of the ~55 kDa beta 2-subunit of the GABAA receptor.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GABA-A R beta 2 Antibody - Azide Free

Western Blot: GABA-A R beta 2 Antibody [NB300-198]

Western Blot: GABA-A R beta 2 Antibody [NB300-198]

Western Blot: GABA-A R beta 2 Antibody [NB300-198] - 7 ug of rat cerebellum (Cb) showing specific immunolabeling of the ~55k beta2-subunit of the GABA-AR.

Applications for GABA-A R beta 2 Antibody - Azide Free

Application
Recommended Usage

Western Blot

1:1000
Application Notes
Immunoprecipitation 15 ug ** ** 68% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Format

Azide Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R beta 2

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Long Name

gamma-Aminobutyric Acid Type A Receptor, beta-2 Polypeptide

Alternate Names

GABAAR beta 2, GABAARb2, GABRB2

Entrez Gene IDs

2561 (Human); 25451 (Rat)

Gene Symbol

GABRB2

UniProt

P63138 (Rat)

Additional GABA-A R beta 2 Products

Product Documents for GABA-A R beta 2 Antibody - Azide Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for GABA-A R beta 2 Antibody - Azide Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

GABA Receptors

Citations for GABA-A R beta 2 Antibody - Azide Free

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FAQs for GABA-A R beta 2 Antibody - Azide Free

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  • Q: Could you please provide the immunogen sequence for Anti-GABA A Receptor beta 3 antibody and Anti-GABA A Receptor beta 2 antibody, catalog number NB300-199 and NB300-198 at your earliest convenience? If the exact sequence is not available, could you please tell me a broader range of amino acids or the region of the peptide from which it is derived? Also, please let me know if this information can be made public. Thank you for your help in this matter.

    A: The immunogen for NB300-199 falls within 340-420 amino acids, while the immunogen for NB300-198 falls within the range of 327-451.

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