Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein

Novus Biologicals | Catalog # NBP3-14780

Novus Biologicals
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Key Product Details

Applications

Western Blot, Functional Assay, Microscopy, SDS-PAGE
View all gamma-Synuclein Proteins and Enzymes »

Product Specifications

Description

A full length recombinant protein of Human gamma-Synuclein

Source: E. coli

Uniprot ID: O76070

Purity

>95%, by SDS-PAGE

Protein / Peptide Type

Recombinant Protein

Scientific Data Images

In vitro assay: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780]

In vitro assay: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780]

In vitro assay: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in gamma synuclein fibrils. Increased fluorescence (correlated to gamma synuclein fibrillization) is seen when human gamma synuclein monomer is combined with human gamma synuclein PFFs (NBP3-14780).
Electron Microscopy: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780] - TEM of Active Human Recombinant gamma-Synuclein Protein Pre-formed Fibrils (Type 1) (NBP3-14780)

Formulation, Preparation, and Storage

NBP3-14780
Preparation Method Ion-exchange Purified
Formulation PBS pH 7.4
Preservative No Preservative
Concentration Please see the vial label for concentration. If unlisted please contact technical services.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: gamma-Synuclein

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. May be a centrosome-associated protein. Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.

Alternate Names

BCSG1, PRSN, SNCG, Synoretin, Synuclein-gamma

Gene Symbol

SNCG

Additional gamma-Synuclein Products

Product Documents

Certificate of Analysis

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Product Specific Notices

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

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