Gliocidin

Key Product Details

Product Description

Gliocidin is an IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor. Gliocidin is a nicotinamide-mimetic prodrug that is anabolized into its tumoricidal metabolite, gliocidin-adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. In vivo, Gliocidin penetrates the blood-brain barrier and extends the survival of mice with orthotopic glioblastoma.

Product Specifications for Gliocidin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Gliocidin

The following data is based on the product molecular weight 204.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.90 mL	24.48 mL	48.96 mL
5 mM	0.98 mL	4.90 mL	9.79 mL
10 mM	0.49 mL	2.45 mL	4.90 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Nature 2024 PMID: 39567689

Product Documents for Gliocidin