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GLPG 0974

Catalog #: 5621 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5621/10
GLPG 0974 | CAS No. 1391076-61-1 | Free Fatty Acid Receptor Antagonists
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Description: Potent FFA2 (GPR43) antagonist

Chemical Name: 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid

Purity: ≥98%

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Biological Activity

GLPG 0974 is a potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.

Technical Data

M.Wt:
485
Formula:
C25H25ClN2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1391076-61-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human FFAR2/GPR43 (NP_005297) VersaClone cDNA

RDC0138

Mouse FFAR2/GPR43 (NP_666299) VersaClone cDNA

RDC0526

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