GLPG 0974

   
Product Datasheet
Catalog Number:5621
Chemical Name:4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid
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Biological Activity
Potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.
Technical Data
  • M.Wt:
    485
  • Formula:
    C25H25ClN2O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1391076-61-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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