Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Biological ActivitySelective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399).
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Zhang et al.
Allosteric interactions between the myristate- and ATP-site of the Abl kinase.
Iacob et al.
PLoS One, 2011;6:e15929
Expanding the diversity of allosteric Bcr-Abl inhibitors.
Deng et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for GNF 5
There are currently no reviews for this product. Be the first to review GNF 5 and earn rewards!
Have you used GNF 5?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image