GR 55562 dihydrochloride

  ( 6 citations )    
Product Datasheet
Catalog Number:1054
Chemical Name:3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
A selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.
Technical Data
  • M.Wt:
    448.39
  • Formula:
    C23H25N3O2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    159533-25-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

6 Citations: Showing 1 - 6
Filter your results:

  1. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.
    Authors: Johansson Et al.
    PLoS One  2012;7:e41852
  2. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Exp Eye Res  2010;85:593
  3. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
    Authors: Wei Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;298:L863
  4. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  5. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  6. Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat.
    Authors: McDaid and Docherty
    Br J Pharmacol  2001;133:429

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used GR 55562 dihydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee