GR 55562 dihydrochloride
Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Biological ActivityGR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
MacLean et al.
The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors.
Walsh et al.
Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction.
Connor et al.
Citations for GR 55562 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:
9 Citations: Showing 1 - 9
Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation.
Authors: Zhou Et al.
Behav Brain Res 2019;356:148
Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands.
Authors: Rataj Et al.
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.
Authors: Johansson Et al.
PLoS One 2012;7:e41852
In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
Authors: Morecroft Et al.
Exp Eye Res 2010;85:593
JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
Authors: Wei Et al.
Am J Physiol Lung Cell Mol Physiol 2010;298:L863
Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
Authors: Guo and Rainnie
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
Authors: Müller Et al.
PLoS One 2009;4:e6453
Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat.
Authors: McDaid and Docherty
Br J Pharmacol 2001;133:429
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