Catalog Number: 1054
Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Biological Activity
A selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.
Technical Data
  • M.Wt:
    448.39
  • Formula:
    C23H25N3O2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    159533-25-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
    MacLean et al.
    Br.J.Pharmacol., 1996;119:277
  2. The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors.
    Walsh et al.
    Eur.J.Pharmacol., 1995;287:79
  3. Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction.
    Connor et al.
    Cephalalgia, 1995;15:99
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

4 Citations: Showing 1 - 4
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  1. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.
    Authors: Johansson Et al.
    PLoS One 2012;7:e41852
  2. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Exp Eye Res 2010;85:593
  3. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
    Authors: Wei Et al.
    Am J Physiol Lung Cell Mol Physiol 2010;298:L863
  4. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One 2009;4:e6453

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