Biological Activity Potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.
Soluble to 20 mM in 1eq. HCl and to 50 mM in DMSO
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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