GSK 2193874

  ( 2 citations )    
Product Datasheet
Catalog Number:5106
Chemical Name:3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
Product Details
Citations (2)
Reviews
Biological Activity
Potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.
Technical Data
  • M.Wt:
    691.62
  • Formula:
    C37H38BrF3N4O
  • Solubility:
    Soluble to 20 mM in 1eq. HCl and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1336960-13-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GSK 2193874 include:

2 Citations: Showing 1 - 2
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  1. A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.
    Authors: Xu Et al.
    Oncotarget  2016;7:37622
  2. Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
    Authors: Chen Et al.
    J Biol Chem  2016;291:10252

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