Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα
values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Collins et al.
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats.
Leik et al.
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph et al.
The citations listed below are publications that use Tocris products. Selected citations for GW 3965 hydrochloride include:
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