Chemical Name: 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole
Biological ActivityPotent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.
Clayton et al.
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Valenzano et al.
Citations for GW 405833
The citations listed below are publications that use Tocris products. Selected citations for GW 405833 include:
4 Citations: Showing 1 - 4
Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.
Authors: Li Et al.
J Pharmacol Exp Ther 2017;362:296
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Authors: Marini Et al.
Br J Pharmacol 2013;169:887
Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
Authors: Schuelert Et al.
Osteoarthritis Cartilage 2010;18:1536
Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
Authors: McGuinness Et al.
Cardiovasc Res 2009;14:49
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