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GW 405833

2374 4 Citations Datasheet / COA / SDS
Newer Version Available: 5826

Discontinued Product

2374 has been discontinued and is replaced by 5826.

GW 405833 | CAS No. 180002-83-9 | Cannabinoid R2/CB2 Agonists
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Description: Selective, high affinity CB2 receptor partial agonist
Alternative Names: L-768,242

Chemical Name: 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Technical Data

M.Wt:
447.36
Formula:
C23H24Cl2N2O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
180002-83-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for GW 405833

The citations listed below are publications that use Tocris products. Selected citations for GW 405833 include:

4 Citations: Showing 1 - 4

  1. Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.
    Authors: Li Et al.
    J Pharmacol Exp Ther  2017;362:296
  2. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  3. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
    Authors: Schuelert Et al.
    Osteoarthritis Cartilage  2010;18:1536
  4. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Cardiovasc Res  2009;14:49

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