GW 405833

  ( 3 citations )    
Product Datasheet
Catalog Number:2374
Alternate Names:L-768,242
Chemical Name:1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.
Technical Data
  • M.Wt:
    447.36
  • Formula:
    C23H24Cl2N2O3
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    180002-83-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 405833 include:

3 Citations: Showing 1 - 3
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  1. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  2. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
    Authors: Schuelert Et al.
    Osteoarthritis Cartilage  2010;18:1536
  3. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Cardiovasc Res  2009;14:49

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