GW 405833

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GW 405833 | CAS No. 180002-83-9 | Cannabinoid R2/CB2 Agonists
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Description: Selective, high affinity CB2 receptor partial agonist
Alternative Names: L-768,242

Chemical Name: 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
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Biological Activity

Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Technical Data

M.Wt:
447.36
Formula:
C23H24Cl2N2O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
180002-83-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for GW 405833

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