Home / Cannabinoid R2/CB2 Agonists / GW 405833

GW 405833

2374 4 Citations Datasheet / COA / SDS
Newer Version Available: 5826
NEW

Discontinued Product

2374 has been discontinued and is replaced by 5826.

GW 405833 | CAS No. 180002-83-9 | Cannabinoid R2/CB2 Agonists
1 Image
Description: Selective, high affinity CB2 receptor partial agonist
Alternative Names: L-768,242

Chemical Name: 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Technical Data

M.Wt:
447.36
Formula:
C23H24Cl2N2O3
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
180002-83-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for GW 405833

The citations listed below are publications that use Tocris products. Selected citations for GW 405833 include:

4 Citations: Showing 1 - 4

  1. Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.
    Authors: Li Et al.
    J Pharmacol Exp Ther  2017;362:296
  2. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  3. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
    Authors: Schuelert Et al.
    Osteoarthritis Cartilage  2010;18:1536
  4. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Cardiovasc Res  2009;14:49

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for GW 405833

There are currently no reviews for this product. Be the first to review GW 405833 and earn rewards!

Have you used GW 405833?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.