Selective melanin-concentrating hormone receptor 1 (MCH1
) antagonist (IC50
= 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.
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Sold for research purposes under agreement from GlaxoSmithKline.
Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity.
Rivera et al.
Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression.
Gehlert et al.