Catalog Number: 4242
Chemical Name: 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
Biological Activity
Selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.
Technical Data
  • M.Wt:
    481.99
  • Formula:
    C25H24ClN3O3S
  • Solubility:
    Soluble to 25 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    515141-51-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity.
    Rivera et al.
    Curr.Med.Chem., 2008;15:1025
  2. Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression.
    Gehlert et al.
    J.Pharmacol.Exp.Ther., 2009;329:429

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