GYKI 52466 dihydrochloride

  ( 13 citations )    
Product Datasheet
Catalog Number:1454
Chemical Name:4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA-, kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™. Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
    366.24
  • Formula:
    C17H15N3O2.2HCl
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in water
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    102771-26-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GYKI 52466 dihydrochloride include:

13 Citations: Showing 1 - 10
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  1. Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway
    Authors: Bao Et al.
    Behavioural Brain Research  2016;317:263
  2. 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.
    Authors: Li Et al.
    Int J Neuropsychopharmacol  2016;19
  3. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
    Authors: Fernandes Et al.
    PLoS One  2014;9:e99958
  4. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain  2011;152:912
  5. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.
    Authors: Lobb Et al.
    J Neurophysiol  2010;104:403
  6. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord.
    Authors: Santos Et al.
    PLoS One  2009;4:e8047
  7. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain.
    Authors: Park Et al.
    Mol Pain  2009;4:67
  8. Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.
    Authors: Lebrun-Julien Et al.
    J Neurosci  2009;29:5536
  9. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
    Authors: Fritsch Et al.
    Neuroscience  2009;163:415
  10. Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores.
    Authors: Lin Et al.
    J Pharmacol Exp Ther  2008;37:770
  11. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior.
    Authors: Du Et al.
    J Neurosci  2008;28:68
  12. AMPA receptor-dependent H2O2 generation in striatal medium spiny neurons but not dopamine axons: one source of a retrograde signal that can inhibit dopamine release.
    Authors: Avshalumov Et al.
    J Neurophysiol  2008;100:1590
  13. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
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