Catalog Number: 0542
Chemical Name: (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride
Biological Activity
Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
    Hidaka et al.
    Biochemistry, 1984;23:5036
  2. The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source.
    Quick et al.
    Biochem.Biophys.Res.Commun., 1992;187:657
  3. Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries.
    Ratz et al.
    J.Pharmacol.Exp.Ther., 1990;252:253

The citations listed below are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:

Showing Results 1 - 2 of 2

  1. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
    Authors: Barcomb Et al.
    Front Mol Neurosci
  2. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
    Authors: Belmeguenai and Hansel
    Mol Pharmacol
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