H-7 dihydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:0542
Chemical Name:(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride
Product Details
Citations (3)
Reviews
Biological Activity
Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively.
Technical Data
  • M.Wt:
    364.29
  • Formula:
    C14H17N3O2S.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    108930-17-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
    Authors: Barcomb Et al.
    Front Mol Neurosci  2013;84:834
  2. Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids.
    Authors: Ludgate Et al.
    J Virol  2012;86:12237
  3. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
    Authors: Belmeguenai and Hansel
    Mol Pharmacol  2005;25:10768

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