H-7 dihydrochloride

Tocris Bioscience | Catalog # 0542

Protein kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Protein kinase inhibitor
View all Broad Spectrum Protein Kinase Inhibitors »

Product Description

H-7 dihydrochloride is a protein kinase inhibitor (IC50 values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 μM, respectively. H-7 shows antiviral activity against influenza A (IC50 = 10 μM) in vitro. H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA-stimulated interleukin 1β production.

Product Specifications for H-7 dihydrochloride

Molecular Weight

364.29

Formula

C14H17N3O2S.2HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride

CAS Number

108930-17-2

PubChem ID

73332

InChI Key

OARGPFMFRLLKPF-UHFFFAOYSA-N

SMILES

Cl.Cl.CC1CNCCN1S(=O)(=O)C1=CC=CC2=CN=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.43 100
DMSO 7.29 20

Preparing Stock Solutions for H-7 dihydrochloride

The following data is based on the product molecular weight 364.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Product Documents for H-7 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H-7 dihydrochloride

For research use only

Citations for H-7 dihydrochloride

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  • H7 was studied for its inhibitory role in cAMP dependent protein kinase
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/24/2019
    Cultures were incubated for 16 hours at 37 ~ in an atmosphere of 5% CO2 and 95% humidified air. 1~tCi of [3H]-thymidine was added to each well and cultures incubated for a further 5 hours. Cells were then harvested onto glass fibre filters, washed and incorporated radioactivity determined by liq- uid scintillation spectrometry.
    H7 was studied for its inhibitory role in cAMP dependent protein kinase with ICso values of 18 and 16 gM respectively.
    H-7 dihydrochloride 0542

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