Potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50
values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α
= 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.
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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.
Everaerts et al.
The citations listed below are publications that use Tocris products. Selected citations for HC 067047 include:
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