Herpes Simplex Virus 1 Antibody

Novus Biologicals | Catalog # NB120-9533

Novus Biologicals
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Key Product Details

Species Reactivity

Virus

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Herpes Simplex Virus 1 Primary Antibodies »

Product Specifications

Immunogen

Whole rabbit corneal cells, infected with herpes simplex virus type I (strain Mac Intyre), were solubilized with detergent.

Localization

Cytoplasmic, nuclear

Specificity

This antibody reacts with Herpes Simplex Virus 1 (HSV1) specific antigens and with antigens common to Herpes Simplex Virus 1 (HSV1) and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Herpes Simplex Virus 1 Antibody

Immunohistochemistry-Paraffin: Herpes Simplex Virus 1 Antibody [NB120-9533]

Immunohistochemistry-Paraffin: Herpes Simplex Virus 1 Antibody [NB120-9533]

Immunohistochemistry-Paraffin: Herpes Simplex Virus 1 Antibody [NB120-9533] - Formalin fixed paraffin embedded tissue stained with HSV I antibody (NB120-9533).

Applications for Herpes Simplex Virus 1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:75-1:200

Immunohistochemistry-Frozen

1:10-1:500

Immunohistochemistry-Paraffin

1:75-1:200
Application Notes
IHC-P: recommended pretreatment of citrate buffer, pH 6.0. Recommended incubation time of 30 min at RT.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 0.2% BSA, Tween-20

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Herpes Simplex Virus 1

Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.

Alternate Names

Herpes simplex virus, Herpes simplex virus 1, Herpes simplex virus type 1, HSV 1, Human herpesvirus 1, Human herpesvirus type 1

Additional Herpes Simplex Virus 1 Products

Product Documents for Herpes Simplex Virus 1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Herpes Simplex Virus 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Herpes Simplex Virus 1 Antibody

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Herpes Simplex Virus 1 Antibody

Showing  1 - 2 of 2 FAQs Showing All

  • Q: The data sheet for this antibody says:
    "This reacts with Herpes Simplex Virus 1 (HSV1) specific antigens and with antigens common to Herpes Simplex Virus 1 (HSV1) and II virus."
    Is this ab useful for HSV1 and HSV2?

    A: this antibody does recognize both the HSV1 and HSV2. So, in regards to HSV1 and IHC, it is accepted that it will cross-react with the common antigens between HSV I and II, along with the unique antigen for HSV1, HSV2 does the same. When used clinically, end users typically cocktail the two.
    Unfortunately, this limits the ability of either antibody to be used as a research IHC tool when studying only HSV1 or HSV2 – the antibodies commercially available for IHC will not distinguish between the two specifically.

  • Q: What is the buffer composition and azide concentration for NB120-9533 (HSV1 Antibody)?

    A: The buffer is PBS supplemented with 2% BSA and 0.05% sodium azide

  • Q: The data sheet for this antibody says:
    "This reacts with Herpes Simplex Virus 1 (HSV1) specific antigens and with antigens common to Herpes Simplex Virus 1 (HSV1) and II virus."
    Is this ab useful for HSV1 and HSV2?

    A: this antibody does recognize both the HSV1 and HSV2. So, in regards to HSV1 and IHC, it is accepted that it will cross-react with the common antigens between HSV I and II, along with the unique antigen for HSV1, HSV2 does the same. When used clinically, end users typically cocktail the two.
    Unfortunately, this limits the ability of either antibody to be used as a research IHC tool when studying only HSV1 or HSV2 – the antibodies commercially available for IHC will not distinguish between the two specifically.

  • Q: What is the buffer composition and azide concentration for NB120-9533 (HSV1 Antibody)?

    A: The buffer is PBS supplemented with 2% BSA and 0.05% sodium azide

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