HLA DQ/DR/DP Antibody (CR3/43)

Novus Biologicals | Catalog # NB120-17101

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # CR3/43
View all HLA DQ/DR/DP Primary Antibodies »

Product Specifications

Immunogen

Tonsil cells

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Localization

Cell Membrane

Specificity

This antibody reacts with the beta chain of all products of the gene sub regions DP, DQ, and DR. It stains B cells, interdigitating reticulum cells, Langerhans cells and many macrophages. This antibody does not react with normal T cell and polymorphs but stains activated T cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for HLA DQ/DR/DP Antibody (CR3/43)

Immunohistochemistry-Paraffin: HLA DQ/DR/DP Antibody (CR3/43) [NB120-17101]

Immunohistochemistry-Paraffin: HLA DQ/DR/DP Antibody (CR3/43) [NB120-17101]

Immunohistochemistry-Paraffin: HLA DQ/DR/DP Antibody (CR3/43) [NB120-17101] - Formalin fixed paraffin embedded human tonsil stained with HLA-DR antibody (NB120-17101).
HLA DQ/DR/DP Antibody (CR3/43)

Immunocytochemistry/ Immunofluorescence: HLA DQ/DR/DP Antibody (CR3/43) [NB120-17101] -

Expression of human leukocyte antigen (HLA) DR/DP/DQ in the developing cochlea. (A, B) Expression of HLA DR/DP/DQ in the E109 and E120 cochlea. No HLA DR/DP/DQ expression is observed in these stages. (C–E) Expression of HLA DR/DP/DQ in the P0 cochlea. At this stage, some macrophages expressed HLA DR/DP/DQ. HLA DR/DP/DQ expression is observed in macrophages in the organ of Corti [Arrow in (D)]. No HLA DR/DP/DQ expression is detected in the perivascular macrophages (PVMs) in the stria vascularis at this stage (E). (F) HLA DR/DP/DQ expression in the postnatal stria vascularis. HLA DR/DP/DQ expression is detected in the postnatal PVMs. Scale Bar: 100 μm in (A–C) 50 μm in (D, E) 20 μm in (F) The nuclei are counterstained with Hoechst (blue). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/37675123), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Applications for HLA DQ/DR/DP Antibody (CR3/43)

Application
Recommended Usage

Immunohistochemistry

1:25-1:50

Immunohistochemistry-Paraffin

1:25-1:50
Application Notes
IHC-P: recommended pretreatment of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: HLA DQ/DR/DP

The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.

Alternate Names

CD, CELIAC1DQ alpha 1 chain, DC-1 alpha chain, DQ-A1, FLJ27088, FLJ27328, GSE, HLA class II histocompatibility antigen, DQ(W3) alpha chain, HLA-DCA, HLA-DQA, leucocyte antigen DQA1, leukocyte antigen alpha chain, major histocompatibility complex, class II, DQ alpha 1, MGC149527, MHC class II antigen, MHC class II DQA1, MHC class II HLA-D alpha glycoprotein, MHC class II HLA-DQ-alpha-1, MHC class II surface glycoprotein, MHC HLA-DQ alpha

Entrez Gene IDs

3119 (Human)

Gene Symbol

HLA-DQA1

UniProt

P01920 (Human)

Additional HLA DQ/DR/DP Products

Product Documents for HLA DQ/DR/DP Antibody (CR3/43)

Certificate of Analysis

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Product Specific Notices for HLA DQ/DR/DP Antibody (CR3/43)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for HLA DQ/DR/DP Antibody (CR3/43)

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Protocols

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FAQs

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