hnRNP M Antibody (2A6-2H3)

Novus Biologicals | Catalog # NBP3-30646

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # 2A6-2H3
View all hnRNP M Primary Antibodies »

Product Specifications

Immunogen

hnRNP M1-4 proteins

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for hnRNP M Antibody (2A6-2H3)

hnRNP M Antibody (2A6-2H3)

Immunoprecipitation:[NBP3-30646]-

Immunoprecipitation:[NBP3-30646]-Detection of human hnRNP M3/4 by western blot of immunoprecipitates. Samples: Whole cell lysate from HEK293T cells prepared using NETN lysis buffer. Antibodies: Mouse anti-hnRNP M3/4 monoclonal antibody [2A6-2H3] used for IP at 20 µl/mg lysate. hnRNP M3/4 was also immunoprecipitated by a previous lot of this antibody and a second antibody against a different epitope of hnRNP M3/4. For blotting immunoprecipitated hnRNP M3/4, was used at 1: 1000. Detection: Chemiluminescence with an exposure time of 1 second.

Applications for hnRNP M Antibody (2A6-2H3)

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-buffered Saline 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: hnRNP M

Proteins that directly bind to nascent RNA polymerase II transcripts--the heterogenous nuclear ribonucleoproteins (hnRNPs)--play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Alternate Names

DKFZp547H118, heterogeneous nuclear ribonucleoprotein M, hnRNP M, HNRNPM4, HNRPM4heterogenous nuclear ribonucleoprotein M, HNRPMheterogenous nuclear ribonucleoprotein M4, HTGR1, M4 protein, N-acetylglucosamine receptor 1, NAGR1hnRNA-binding protein M4

Gene Symbol

HNRNPM

Additional hnRNP M Products

Product Documents for hnRNP M Antibody (2A6-2H3)

Certificate of Analysis

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Product Specific Notices for hnRNP M Antibody (2A6-2H3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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