Human ADAMTS10 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB5270U Datasheet / COA / SDS

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FAB5270U-100UG

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All ADAMTS10 Antibodies

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Human ADAMTS10 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human ADAMTS10 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human ADAMTS1, 3, 4, 5, 12, 13, 15, 16, or L2 is observed.

Source

Monoclonal Mouse IgG1 Clone # 496708

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS10
Phe26-Gly1102
Accession # Q9H324

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ADAMTS10

ADAMTS10 belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent metalloproteases. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Mutations in the ADAMTS10 gene may cause autosomal recessive Weill-Marchesani syndrome. The amino acid sequence of human ADAMTS10 is 100%, 96% and 94% identical to that of chimpanzee, dog and mouse.

Long Name

A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 10

Entrez Gene IDs

81794 (Human); 224697 (Mouse); 362847 (Rat)

Alternate Names

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; ADAM-TS 10; ADAMTS10; ADAMTS-10; ADAM-TS10A disintegrin and metalloproteinase with thrombospondin motifs 10; EC 3.4.24.-; EC 3.4.24.82; WMS; zinc metalloendopeptidase