Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Human ALK/CD246 (NP_004295) VersaClone cDNA
R&D Systems | Catalog # RDC1376
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: ALK/CD246
Long Name
Anaplastic Lymphoma Kinase
Alternate Names
CD246, Ki-1, Tcrz
Gene Symbol
ALK
UniProt
Additional ALK/CD246 Products
Product Documents for Human ALK/CD246 (NP_004295) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human ALK/CD246 (NP_004295) VersaClone cDNA
For research use only
Related Research Areas
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