Human APP/Protease Nexin II (Research Grade Aducanumab Biosimilar) Antibody

Recombinant Monoclonal Antibody For Research Use Only
Catalog # Availability Size / Price Qty
MAB9710-100
MAB9710-SP
Detection of APP/Protease Nexin II (Aducanumab) in Human PBMC by Flow Cytometry
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Human APP/Protease Nexin II (Research Grade Aducanumab Biosimilar) Antibody Summary

Species Reactivity
Human
Specificity
Detects human APP/Protease Nexin II based on Aducanumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Aducanumab. This product is for research use only.
Source
Recombinant Monoclonal Human IgG1 Clone # Hu15
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Human APP/Protease Nexin II
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of APP/Protease Nexin II (Aducanumab) in Human PBMC by Flow Cytometry View Larger

Detection of APP/Protease Nexin II (Aducanumab) in Human PBMC by Flow Cytometry Human peripheral blood mononuclear cells (PBMCs) were stained with (A) Human Anti-Human APP/Protease Nexin II (Aducanumab Biosimilar) Monoclonal Antibody (Catalog # MAB9710) or (B) no primary antibody, followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135) and Mouse anti-Human CD14 PE-conjugated antibody (Catalog # FAB3832P). View our protocol for Staining Membrane-associated Proteins.   

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: APP

Aducanumab is a biosimilar directed against the extracellular domain of APP/Protease Nexin II. This product constitutes the immunogen used for the anti-Idiotype catalog number MAB9545.

Long Name
Amyloid Precursor Protein
Entrez Gene IDs
351 (Human); 11820 (Mouse)
Alternate Names
amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta A4 precursor protein-binding family B member 2; Amyloid beta precursor protein; Amyloid beta; APP; beta Amyloid; Protease Nexin II

Product Datasheets

FAQs

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Reconstitution Buffers

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