B7-H4, also known as B7x and B7S1, is an immune costimulatory protein that is expressed on the surface of activated lymphocytes, macrophages, monocytes, dendritic cells, epithelial cells, and bone marrow-derived mesenchymal stem cells. Its binding to activated T cells dampens T cell responses and induces cell cycle arrest in the T cell. Reverse signaling can induce either cell cycle arrest or apoptosis in the B7-H4 expressing cell. B7-H4 is upregulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 functions as a decoy molecule and is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients.
Human B7-H4 (NP_078902) VersaClone cDNA
R&D Systems | Catalog # RDC0687
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: B7-H4
Long Name
B7 Homolog 4
Alternate Names
B7H4, B7S1, B7x, Vtcn1
Gene Symbol
VTCN1
UniProt
Additional B7-H4 Products
Product Documents for Human B7-H4 (NP_078902) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human B7-H4 (NP_078902) VersaClone cDNA
For research use only
Related Research Areas
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