Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA

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Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA
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Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA Summary


Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: beta-Arrestin 2

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta-Arrestin 1), Arrestin 3 (beta-Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta-Arrestins 1 and 2 are ubiquitously expressed, and were initially described as negative regulators of G protein-coupled receptor (GPCR) signaling.

More recently, beta-Arrestins have been determined to serve as scaffolds for various signaling pathways, including the MAPK cascades activating ERK2, p38a, and JNK3. These beta-Arrestin scaffolds tie together the appropriate kinases in series, forming a discreet signaling module that localizes components to specific subcellular environments and facilitates greater kinase activation.

Entrez Gene IDs
409 (Human); 216869 (Mouse); 25388 (Rat)
Alternate Names
ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; betaArrestin 2; beta-Arrestin 2; beta-arrestin-2; DKFZp686L0365


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