beta-Arrestin 2: Products

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta-Arrestin 1), Arrestin 3 (beta-Arrestin 2), and Arrestin 4 (cone Arrestin).

More recently, beta-Arrestins have been determined to serve as scaffolds for various signaling pathways, including the MAPK cascades activating ERK2, p38a, and JNK3. These beta-Arrestin scaffolds tie together the appropriate kinases in series, forming a discreet signaling module that localizes components to specific subcellular environments and facilitates greater kinase activation.

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