Human beta-TrCP1/BTRC (NP_378663.1) VersaClone cDNA

R&D Systems | Catalog # RDC3784

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Key Product Details

Species

Human

Accession Number

NP_378663.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: beta-TrCP1/BTRC

betaTrCP encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq]

Long Name

Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase

Alternate Names

betaTrCP1, BTRC, BTRCP, E3RSIkappaB, FBW1A, FBXW1A, FWD1

Entrez Gene IDs

8945 (Human); 12234 (Mouse); 361765 (Rat)

Gene Symbol

BTRC

UniProt

NP_378663.1

Additional beta-TrCP1/BTRC Products

Product Documents for Human beta-TrCP1/BTRC (NP_378663.1) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human beta-TrCP1/BTRC (NP_378663.1) VersaClone cDNA

For research use only

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