Human Caspr1 Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # FAB7548AFP405

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 753232
View all Caspr1 Primary Antibodies »

Product Specifications

Specificity

Detects human Caspr1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Caspr2 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human Caspr1 Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Caspr1

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). Mature human Caspr1 consists of a 1264 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and an 80 aa cytoplasmic domain. The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain. Within the ECD, human Caspr1 shares 95% aa sequence identity with mouse and rat Caspr1.

Long Name

Contactin Associated Protein-like 1

Alternate Names

CNTNAP, CNTNAP1, p190

Entrez Gene IDs

8506 (Human); 53321 (Mouse)

Gene Symbol

CNTNAP1

UniProt

P78357 (Human)

Additional Caspr1 Products

Product Documents for Human Caspr1 Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Caspr1 Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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