Human CD46 Alexa Fluor® 647-conjugated Antibody

FAB2005R Datasheet / COA / SDS

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FAB2005R-100UG

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Human CD46 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CD46 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 344519

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CD46
Cys35-Asp328
Accession # NP_722548

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

Human whole blood monocytes

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CD46

CD46, also known as MCP, is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The extracellular region of CD46 contains four tandem Sushi domains. At least fourteen transcript variants encode isoforms with deletions or substitutions following the fourth Sushi domain. Within corresponding regions, human CD46 shares 50% amino acid sequence identity with mouse and rat CD46.

Entrez Gene IDs

4179 (Human); 17221 (Mouse)

Alternate Names

AHUS2; CD46 antigen; CD46 molecule, complement regulatory protein; CD46; MCP; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLXcomplement regulatory protein; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen