Human CD46 Antibody
Human CD46 Antibody Summary
Accession # NP_722548
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CD46, also known as MCP, is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The extracellular region of CD46 contains four tandem Sushi domains. At least fourteen transcript variants encode isoforms with deletions or substitutions following the fourth Sushi domain. Within corresponding regions, human CD46 shares 50% amino acid sequence identity with mouse and rat CD46.
Citations for Human CD46 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus
Authors: U Ellinghaus, A Cortini, CL Pinder, GL Friec, C Kemper, TJ Vyse
Eur. J. Immunol., 2017;0(0):.
Sample Types: Whole Cells
Applications: Functional Assay
A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b.
Authors: Johnson J, Borisevich V, Rockx B, Parks G
J Virol, 2015;89(2):989-98.
Sample Types: Serum
Applications: Western Blot
The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization.
Authors: Johnson JB, Grant K, Parks GD
J. Virol., 2009;83(15):7602-11.
Sample Types: Whole Cells
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