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CFHR5 Alexa Fluor® 647-conjugated Antibody

Human Complement Factor H-related 5/
CFHR5 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB3845R Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB3845R-100UG

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Human Complement Factor H-related 5/
CFHR5 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Complement Factor H-related 5/CFHR5 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG1 Clone # 390513
Purification
Protein A or G purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 5/CFHR5
Glu19-Glu569
Accession # Q9BXR6
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration
Sample
Western Blot
Optimal dilution of this antibody should be experimentally determined.
 
Immunoprecipitation
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Complement Factor H-related 5/CFHR5

Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family.  It is secreted by the liver and circulates either free or bound to HDL.  It is unique among FHR proteins in that it associates with complexes that arise from complement activation.  It promotes C3b cleavage and blocks C3 convertase activity.  Human CFHR5 is 551 amino acids (aa) in length.  It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin.  The complement interaction site(s) is unknown.  Human CFHR5 shares 64% aa sequence identity with canine CFHR5.

Entrez Gene IDs
81494 (Human)
Alternate Names
CFHL5; CFHL5factor H-related protein 5; CFHR5; Complement Factor Hrelated 5; Complement Factor H-related 5; FHR5; FHR-5complement factor H-related protein 5; FHR5MGC133240; FLJ10549

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CFHR5 Alexa Fluor® 647-conjugated Antibody

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