Human Complement Factor H-related 5/
CFHR5 Antibody

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Product Details
Citations (3)
Supplemental Products

Human Complement Factor H-related 5/
CFHR5 Antibody Summary

Species Reactivity
Detects human Complement Factor H-related 5/CFHR5 in direct ELISAs and Western blots.
Monoclonal Mouse IgG1 Clone # 390513
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 5/CFHR5
Accession # Q9BXR6
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human Complement Factor H-related 5/CFHR5 (Catalog # 3845-F5) under non-reducing conditions only
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Complement Factor H‑related 5/CFHR5 (Catalog # 3845-F5), see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Factor H-related 5/CFHR5

Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family.  It is secreted by the liver and circulates either free or bound to HDL.  It is unique among FHR proteins in that it associates with complexes that arise from complement activation.  It promotes C3b cleavage and blocks C3 convertase activity.  Human CFHR5 is 551 amino acids (aa) in length.  It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin.  The complement interaction site(s) is unknown.  Human CFHR5 shares 64% aa sequence identity with canine CFHR5.

Entrez Gene IDs
81494 (Human)
Alternate Names
CFHL5; CFHL5factor H-related protein 5; CFHR5; Complement Factor Hrelated 5; Complement Factor H-related 5; FHR5; FHR-5complement factor H-related protein 5; FHR5MGC133240; FLJ10549

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Citations for Human Complement Factor H-related 5/
CFHR5 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
    Authors: Iglesias, MJ;Sanchez-Rivera, L;Ibrahim-Kosta, M;Naudin, C;Munsch, G;Goumidi, L;Farm, M;Smith, PM;Thibord, F;Kral-Pointner, JB;Hong, MG;Suchon, P;Germain, M;Schottmaier, W;Dusart, P;Boland, A;Kotol, D;Edfors, F;Koprulu, M;Pietzner, M;Langenberg, C;Damrauer, SM;Johnson, AD;Klarin, DM;Smith, NL;Smadja, DM;Holmström, M;Magnusson, M;Silveira, A;Uhlén, M;Renné, T;Martinez-Perez, A;Emmerich, J;Deleuze, JF;Antovic, J;Soria Fernandez, JM;Assinger, A;Schwenk, JM;Souto Andres, JC;Morange, PE;Butler, LM;Trégouët, DA;Odeberg, J;
    Nature communications
    Species: Human
    Sample Types: Plasma, Recombinant Protein
    Applications: Mass Spectrometry, Western Blot, ELISA
  2. Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.
    Authors: Chen Q, Manzke M, Hartmann A, Buttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel P
    J Am Soc Nephrol, 2015-10-02;27(5):1413-25.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  3. Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.
    Authors: Csincsi A, Kopp A, Zoldi M, Banlaki Z, Uzonyi B, Hebecker M, Caesar J, Pickering M, Daigo K, Hamakubo T, Lea S, Goicoechea de Jorge E, Jozsi M
    J Immunol, 2015-04-08;194(10):4963-73.


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CFHR5 Antibody

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