Human CtBP1 Alexa Fluor® 750-conjugated Antibody

Catalog #: AF4639S Datasheet / COA / SDS

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AF4639S-100UG

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All CtBP1 Antibodies

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Human CtBP1 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human and mouse CtBP1 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human CtBP2 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human CtBP1
Met1-Leu440
Accession # Q13363

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CtBP1

CtBP1 (C terminal binding protein 1) was originally identified through its binding to the Adenovirus E1A oncoprotein via a 5 amino acid motif, PLDLS, which repressed E1A induced oncogenesis and cellular transformation. In the nucleus, CtBP1 functions predominantly as a transcriptional corepressor in conjunction with a variety of DNA binding repressors.Interaction with Pnn/DRS may modulate repression of E-cadherin by CtBP1. Recruitment of CtBP1 and HDAC to Smad1/Smad4 complexes by Smad6 results in inhibition of BMP stimulated gene expression. The interaction of CtBP1 with polycomb group proteins suggests it is a component of the chromatin remodeling machinery and transcriptional repression. Cytosolic CtBP1 has also been shown to be involved with CNS synapses, membrane trafficking, and regulation of the microtubule cytoskeleton.

Long Name

C-terminal-Binding Protein 1

Entrez Gene IDs

1487 (Human); 13016 (Mouse); 29382 (Rat)

Alternate Names

BARS; brefeldin A-ribosylated substrate; CTBP; CtBP1; C-terminal binding protein 1; C-terminal-binding protein 1; EC 1.1.1; EC 1.1.1.-; EC 1.1.1.158; MGC104684