Human CXCL10/IP-10 Quantikine ELISA Kit DIP100: R&D Systems
  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (10 uL), Serum (75 uL), EDTA Plasma (75 uL), Heparin Plasma (75 uL), Saliva (10 uL), Urine (100 uL)
  • Sensitivity
    4.46 pg/mL
  • Assay Range
    7.8 - 500 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva)
  • Specificity
    Natural and recombinant human IP-10
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Control Available
QC23, Quantikine Immunoassay Control Group 8 - Please Inquire
Product Summary
The Quantikine Human IP-10 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IP-10 in cell culture supernates, serum, plasma, saliva, and urine. It contains E. coli-expressed recombinant human IP-10 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IP-10 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring IP-10.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020404040
Mean67.416833470.7182366
Standard Deviation3.124.9911.156.2311.1218.93
CV%4.633.38.86.15.2

Cell Culture Supernates, Saliva, Urine
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020404040
Mean70.317434280.7194362
Standard Deviation2.075.1510.747.9113.4824.27
CV%2.933.19.86.96.7

Recovery

The recovery of IP-10 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 95 88-101
EDTA Plasma (n=5) 99 90-109
Heparin Plasma (n=5) 99 87-113
Serum (n=5) 99 88-112
Linearity
To assess the linearity of the assay, samples containing and/or spiked with high concentrations of IP-10 were serially diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human CXCL10/IP-10 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: CXCL10/IP-10/CRG-2
IP-10 was originally identified as an IFN-gamma-inducible gene in monocytes, fibroblasts and endothelial cells. The mouse homolog of human IP-10, CRG-2, shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of IP-10 identified the protein as a member of the CXC chemokine subfamily.
    • Entrez Gene IDs
      3627 (Human); 15945 (Mouse);
    • Alternate Names
      C7; chemokine (C-X-C motif) ligand 10; CRG2; CRG-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. Assay Diluent
    4.   For Cell Culture Supernate, Saliva, & Urine Samples: Add 150 µL of Assay Diluent to each well.
      For Serum & Plasma Samples: Add 75 µL of Assay Diluent to each well.

    5. Standard, Control, or Sample
    6.   For Cell Culture Supernate, Saliva, & Urine Samples: Add 100 µL of Standard, control, or sample to each well.
      For Serum & Plasma Samples: Add 75 µL of Standard, control, or sample to each well.
    7.   Cover with a plate sealer, and incubate at room temperature for 2 hours.
    8.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.

    9. 200 µL Conjugate
    10.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    11.   Aspirate and wash 4 times.

    12. 200 µL Substrate Solution
    13.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    14. 50 µL Stop Solution
    15. Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    86 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. Impact of hepatitis B vaccination on HBsAg kinetics, interferon-inducible protein 10 level and recurrence of viremia
      Authors: A Shaaban Ha
      Cytokine, 2017;99(0):99-105.
      Species: Human
      Sample Type: Serum
    2. Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 signaling pathway in proximal tubular cells
      Authors: Y Arai, D Takahashi, K Asano, M Tanaka, M Oda, SBH Ko, MSH Ko, S Mandai, N Nomura, T Rai, S Uchida, E Sohara
      Sci Rep, 2017;7(0):46580.
      Species: Human
      Sample Type: Cell Culture Supernates
    3. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
      Authors: K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale
      BMC Infect. Dis, 2017;17(1):228.
      Species: Human
      Sample Type: Serum
    4. Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers
      Authors: MR Pranzatell, ED Tate, TJ Allison
      Cytokine, 2017;96(0):49-53.
      Species: Human
      Sample Type: CSF
    5. Interferon-alpha treatment rapidly clears Hepatitis E virus infection in humanized mice
      Authors: MDB van de Gar, SD Pas, GW van Oord, L Gama, Y Choi, RA de Man, A Boonstra, T Vanwollegh
      Sci Rep, 2017;7(1):8267.
      Species: Mouse
      Sample Type: Serum
    6. Changes in inflammatory biomarkers in HCV-infected patients undergoing direct acting antiviral-containing regimens with or without interferon
      Authors: C Mascia, S Vita, P Zuccalà, R Marocco, T Tieghi, S Savinelli, R Rossi, M Iannetta, I Pozzetto, C Furlan, F Mengoni, CM Mastroiann, V Vullo, M Lichtner
      PLoS ONE, 2017;12(6):e0179400.
      Species: Human
      Sample Type: Plasma
    7. Predictive Value of Serum IFN-? inducible Protein-10 and IFN-?/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients
      Authors: Y Wang, W Yu, C Shen, W Wang, L Zhang, F Liu, H Sun, Y Zhao, H Che, C Zhao
      Sci Rep, 2017;7(0):40404.
      Species: Human
      Sample Type: Serum
    8. Impact of early cART on HIV blood and semen compartments at the time of primary infection
      Authors: A Chéret, C Durier, A Mélard, M Ploquin, J Heitzmann, C Lécuroux, V Avettand-F, L David, G Pialoux, JM Chennebaul, M Müller-Tru, C Goujard, C Rouzioux, L Meyer,
      PLoS ONE, 2017;12(7):e0180191.
      Species: Human
      Sample Type: Plasma
    9. Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration
      J Control Release, 2016;239(0):137-148.
      Species: Human
      Sample Type: Cell Culture Supernates
    10. Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection
      PLoS ONE, 2016;11(5):e0155142.
      Species: Human
      Sample Type: Plasma
    11. Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset
      PLoS Pathog, 2016;12(8):e1005774.
      Species: Human
      Sample Type: Plasma
    12. Small Ubiquitin-like Modifier Alters IFN Response.
      Authors: Maarifi G, Maroui M, Dutrieux J, Dianoux L, Nisole S, Chelbi-Alix M
      J Immunol, 2015;195(5):2312-24.
      Species: Human
      Sample Type: Cell Culture Supernates
    13. Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1.
      Authors: Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A
      PLoS ONE, 2015;10(7):e0131201.
      Species: Human
      Sample Type: Cell Culture Supernates
    14. Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study.
      Authors: Altara R, Gu Y, Struijker-Boudier H, Thijs L, Staessen J, Blankesteijn W
      PLoS ONE, 2015;10(10):e0141394.
      Species: Human
      Sample Type: Plasma
    15. Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
      Authors: Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Morgelin M, Johansson-Lindbom B, Egesten A, Herwald H
      PLoS Pathog, 2015;11(12):e1005319.
      Species: Human
      Sample Type: Plasma
    16. Tumor necrosis factor (TNF)-alpha induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-kappaB p65 methylation.
      Authors: Harris D, Bandyopadhyay S, Maxwell T, Willard B, DiCorleto P
      J Biol Chem, 2014;289(22):15328-39.
      Species: Human
      Sample Type: Cell Culture Supernates
    17. Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.
      Authors: Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John
      PLoS ONE, 2014;9(5):e96737.
      Species: Human
      Sample Type: Cell Culture Supernates
    18. Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
      Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
      PLoS ONE, 2014;9(12):e115226.
      Species: Human
      Sample Type: Plasma
    19. Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.
      Authors: Grammatikos G, Lange C, Susser S, Schwendy S, Dikopoulos N, Buggisch P, Encke J, Teuber G, Goeser T, Thimme R, Klinker H, Boecher W, Schulte-Frohlinde E, Penna-Martinez M, Badenhoop K, Zeuzem S, Berg T, Sarrazin C
      PLoS ONE, 2014;9(2):e87974.
      Species: Human
      Sample Type: Serum
    20. Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL is a biologically functional cut-point.
      Authors: Hermanrud C, Ryner M, Engdahl E, Fogdell-Hahn A
      J Interferon Cytokine Res, 2014;34(7):498-504.
      Species: Human
      Sample Type: Serum
    21. Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation.
      Authors: Gluzman-Poltorak Z, Mendonca S, Vainstein V, Kha H, Basile L
      J Hematol Oncol, 2014;7(0):31.
      Species: Primate - Macaca mulatta (Rhesus Macaque)
      Sample Type: Plasma
    22. Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
      Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
      BMC Biotechnol, 2014;14(0):63.
      Species: Human
      Sample Type: Serum
    23. BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
      Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
      J Neuroinflammation, 2013;10(0):10.
      Species: Human
      Sample Type: Serum
    24. CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria.
      Authors: Wilson N, Driss A, Solomon W, Dickinson-Copeland C, Salifu H, Jain V, Singh N, Stiles J
      PLoS ONE, 2013;8(12):e81329.
      Species: Human
      Sample Type: Plasma
    25. Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10.
      Authors: Antonelli A, Fallahi P, Ferrari S, Colaci M, Giuggioli D, Saraceno G, Benvenga S, Ferri C
      J Interferon Cytokine Res, 2013;33(12):739-45.
      Species: Human
      Sample Type: Serum
    26. Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome.
      Authors: Pranzatelli M, Tate E, McGee N, Travelstead A, Verhulst S, Ransohoff R
      Clin Exp Immunol, 2013;172(3):427-36.
      Species: Human
      Sample Type: Serum
    27. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
      Authors: Chaturvedi, Pallavi, Gilkes, Daniele, Wong, Carmen C, Luo, Weibo, Zhang, Huafeng, Wei, Hong, Takano, Naoharu, Schito, Luana, Levchenko, Andre, Semenza, Gregg L
      J Clin Invest, 2013;123(1):189-205.
      Species: Human
      Sample Type: Cell Culture Supernates
    28. Cleaved/associated TLR3 represents the primary form of the signaling receptor.
      Authors: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli M, Zhang S, Funami K, Seya T, Matsumoto M, Pin J, Casanova J, Renno T, Lebecque S
      J Immunol, 2013;190(2):764-73.
      Species: Human
      Sample Type: Cell Culture Supernates
    29. A20/TNFAIP3 inhibits NF-kappaB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.
      Authors: Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick T, Yarchoan R, Tosato G
      Oncogene, 2013;32(10):1223-32.
      Species: Human
      Sample Type: Whole Cells
    30. Human trophectoderm apposition is regulated by interferon gamma-induced protein 10 (IP-10) during early implantation.
      Authors: Sela H, Goldman-Wohl D, Haimov-Kochman R, Greenfield C, Natanson-Yaron S, Hamani Y, Revel A, Lavy Y, Singer O, Yachimovich-Cohen N, Turetsky T, Mandelboim O, Reubinoff B, Yagel S
      Placenta, 2013;34(3):222-30.
      Species: Human
      Sample Type: Cell Culture Supernates
    31. Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees.
      Authors: Verstrepen B, De Groot N, Groothuismink Z, Verschoor E, de Groen R, Bogers W, Janssen H, Mooij P, Bontrop R, Koopman G, Boonstra A
      PLoS ONE, 2012;7(10):e46645.
      Species: Human
      Sample Type: Serum
    32. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.
      Authors: Santin I, Moore F, Grieco F, Marchetti P, Brancolini C, Eizirik D
      Cell Death Dis, 2012;3(0):e419.
      Species: Human
      Sample Type: Cell Culture Supernates
    33. Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus.
      Authors: Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J
      J. Invest. Dermatol., 2011;131(1):133-40.
      Species: Human
      Sample Type: Cell Culture Supernates
    34. Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10.
      Authors: Antonelli A, Ferrari SM, Frascerra S, Galetta F, Franzoni F, Corrado A, Miccoli M, Benvenga S, Paolicchi A, Ferrannini E, Fallahi P
      Cytokine, 2011;55(2):288-93.
      Species: Human
      Sample Type: Serum
    35. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma.
      Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C
      PLoS Pathog., 2011;7(4):e1002016.
      Species: Human
      Sample Type: Cell Culture Supernates
    36. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
      Authors: Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W
      J. Clin. Invest., 2010;120(5):1645-62.
      Species: Human
      Sample Type: Cell Culture Supernates
    37. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.
      Authors: Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, Park HY, Pflugfelder SC
      Invest. Ophthalmol. Vis. Sci., 2010;51(2):643-50.
      Species: Human
      Sample Type: Tears
    38. CD14-independent responses induced by a synthetic lipid A mimetic.
      Authors: Legat A, Thomas S, Hermand P, Van Mechelen M, Goldman M, De Wit D
      Eur J Immunol, 2010;40(3):797-802.
      Species: Human
      Sample Type: Cell Culture Supernates
    39. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
      Authors: Tso GH, Law HK, Tu W
      Stem Cells, 2010;28(5):939-54.
      Species: Human
      Sample Type: Cell Culture Supernates
    40. Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
      Authors: Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS
      AIDS, 2010;24(7):1001-5.
      Species: Human
      Sample Type: CSF
    41. Interleukin-1beta, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis.
      Authors: Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P
      J. Interferon Cytokine Res., 2010;30(11):835-42.
      Species: Human
      Sample Type: Serum
    42. Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD.
      Authors: Quint JK, Donaldson GC, Goldring JJ, Baghai-Ravary R, Hurst JR, Wedzicha JA
      Chest, 2010;137(4):812-22.
      Species: Human
      Sample Type: Serum
    43. Synthesis and immunological activities of novel agonists of toll-like receptor 9.
      Authors: Struthers M, Bett AJ, Wisniewski T, Dubey SA, Precopio M, Jiang W, Sun Z, Wang H, Nowak I, Putta MR, Yu D, Tang JX, Kandimalla ER, Agrawal S, Casimiro DR
      Cell. Immunol., 2010;263(1):105-13.
      Species: Primate - Macaca mulatta (Rhesus Macaque)
      Sample Type: Cell Culture Supernates
    44. CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis.
      Authors: Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Pampana A, Panicucci E, Carpi A, Nicolini A, Ferrannini E
      J. Interferon Cytokine Res., 2009;29(6):345-51.
      Species: Human
      Sample Type: Serum
    45. Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
      Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
      J. Allergy Clin. Immunol., 2009;124(2):260-9, 269.e1.
      Species: Human
      Sample Type: Serum
    46. The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
      Authors: Lee SH, Kim JS, Jun HK
      J. Immunol., 2009;182(9):5823-35.
      Species: Human
      Sample Type: Cell Culture Supernates
    47. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.
      Authors: Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS
      J. Immunol., 2009;182(6):3919-27.
      Species: Human
      Sample Type: Plasma
    48. CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis.
      Authors: Busuttil A, Weigt SS, Keane MP, Xue YY, Palchevskiy V, Burdick MD, Huang C, Zisman DA, Fishbein M, Lynch JP, Strieter RM, Elashoff RM, Belperio JA
      Eur. Respir. J., 2009;34(3):676-86.
      Species: Human
      Sample Type: BALF
    49. The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
      Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
      Mediators Inflamm., 2009;2009(0):269541.
      Species: Human
      Sample Type: Serum
    50. Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus.
      Authors: Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M
      Arthritis Rheum., 2008;58(10):3205-15.
      Species: Human
      Sample Type: Cell Culture Supernates
    51. The antibacterial chemokine MIG/CXCL9 is constitutively expressed in epithelial cells of the male urogenital tract and is present in seminal plasma.
      Authors: Linge HM, Collin M, Giwercman A, Malm J, Bjartell A, Egesten A
      J. Interferon Cytokine Res., 2008;28(3):191-6.
      Species: Human
      Sample Type: Seminal Plasma
    52. In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
      Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
      J. Interferon Cytokine Res., 2008;28(5):297-310.
      Species: Human
      Sample Type: Cell Culture Supernates
    53. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
      Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
      J. Neuroimmunol., 2008;199(1):35-45.
      Species: Human
      Sample Type: Cell Culture Supernates
    54. Urinary fractalkine is a marker of acute rejection.
      Authors: Peng W, Chen J, Jiang Y, Wu J, Shou Z, He Q, Wang Y, Chen Y, Wang H
      Kidney Int., 2008;74(11):1454-60.
      Species: Human
      Sample Type: Urine
    55. Endometrial NK cells are special immature cells that await pregnancy.
      Authors: Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
      J. Immunol., 2008;181(3):1869-76.
      Species: Human
      Sample Type: Cell Culture Supernates
    56. Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
      Authors: Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M
      J. Immunol., 2008;180(10):6903-10.
      Species: Human
      Sample Type: Cell Culture Supernates
    57. Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma.
      Authors: Little RF, Aleman K, Kumar P, Wyvill KM, Pluda JM, Read-Connole E, Wang V, Pittaluga S, Catanzaro AT, Steinberg SM, Yarchoan R
      Blood, 2007;110(13):4165-71.
      Species: Human
      Sample Type: Serum
    58. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.
      Authors: Costa C, Rufino R, Traves SL, Lapa E Silva JR, Barnes PJ, Donnelly LE
      Chest, 2007;133(1):26-33.
      Species: Human
      Sample Type: Saliva
    59. First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.
      Authors: Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS
      Clin. Cancer Res., 2007;13(23):7119-25.
      Species: Human
      Sample Type: Serum
    60. Airway dendritic cell phenotypes in inflammatory diseases of the human lung.
      Authors: Lommatzsch M, Bratke K, Bier A, Julius P, Kuepper M, Luttmann W, Virchow JC
      Eur. Respir. J., 2007;30(5):878-86.
      Species: Human
      Sample Type: BALF
    61. Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis.
      Authors: Corvino CL, Mamoni RL, Fagundes GZ, Blotta MH
      Clin. Exp. Immunol., 2007;147(3):483-90.
      Species: Human
      Sample Type: Serum
    62. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes.
      Authors: Kanda N, Watanabe S
      Endocrinology, 2007;148(5):2317-25.
      Species: Human
      Sample Type: Cell Culture Supernates
    63. The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells.
      Authors: Simpkins FA, Devoogdt NM, Rasool N, Tchabo NE, Alejandro EU, Kamrava MM, Kohn EC
      Carcinogenesis, 2007;29(3):466-72.
      Species: Human
      Sample Type: Cell Culture Supernates
    64. Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells.
      Authors: Mezger M, Steffens M, Beyer M, Manger C, Eberle J, Toliat MR, Wienker TF, Ljungman P, Hebart H, Dornbusch HJ, Einsele H, Loeffler J
      Blood, 2007;111(2):534-6.
      Species: Human
      Sample Type: Serum
    65. Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis.
      Authors: Barrera L, Mendoza F, Zuniga J, Estrada A, Zamora AC, Melendro EI, Ramirez R, Pardo A, Selman M
      Am. J. Respir. Crit. Care Med., 2007;177(1):44-55.
      Species: Human
      Sample Type: BALF
    66. IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
      Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
      J. Immunol., 2007;178(2):1172-9.
      Species: Human
      Sample Type: Cell Culture Supernates
    67. Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
      Authors: Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A
      Blood, 2007;111(4):2339-46.
      Species: Human
      Sample Type: Cell Culture Supernates
    68. Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis.
      Authors: Lepej SZ, Misic-Majerus L, Jeren T, Rode OD, Remenar A, Sporec V, Vince A
      Acta Neurol. Scand., 2007;115(2):109-14.
    69. Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis.
      Authors: Matsuda A, Fukuda S, Matsumoto K, Saito H
      Am. J. Respir. Cell Mol. Biol., 2007;38(2):168-75.
      Species: Human
      Sample Type: Cell Culture Supernates
    70. Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
      Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
      Stem Cells, 2007;26(1):279-89.
      Species: Human
      Sample Type: Cell Culture Supernates
    71. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
      Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
      Blood, 2006;108(3):947-55.
      Species: Human
      Sample Type: Cell Culture Supernates
    72. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.
      Authors: Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM, Pal S
      Cancer Res., 2006;66(19):9509-18.
      Species: Human
      Sample Type: Cell Culture Supernates
    73. Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
      Authors: Antoniou KM, Tzouvelekis A, Alexandrakis MG, Sfiridaki K, Tsiligianni I, Rachiotis G, Tzanakis N, Bouros D, Milic-Emili J, Siafakas NM
      Chest, 2006;130(4):982-8.
      Species: Human
      Sample Type: BALF
    74. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
      Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
      Exp. Hematol., 2006;34(8):1115-24.
      Species: Human
      Sample Type: Cell Culture Supernates
    75. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
      Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
      J. Immunol., 2005;175(9):6177-89.
      Species: Human
      Sample Type: Cell Culture Supernates
    76. Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques.
      Authors: Sui Y, Li S, Pinson D, Adany I, Li Z, Villinger F, Narayan O, Buch S
      Am. J. Pathol., 2005;166(2):355-65.
      Species: Primate - Macaca mulatta (Rhesus Macaque)
      Sample Type: Tissue Homogenates
    77. Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells.
      Authors: Abel K, Wang Y, Fritts L, Sanchez E, Chung E, Fitzgerald-Bocarsly P, Krieg AM, Miller CJ
      Clin. Diagn. Lab. Immunol., 2005;12(5):606-21.
      Species: Primate - Macaca mulatta (Rhesus Macaque)
      Sample Type: Cell Culture Supernates
    78. CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo.
      Authors: Hartmann G, Marschner A, Viveros PR, Stahl-Hennig C, Eisenblatter M, Suh YS, Endres S, Tenner-Racz K, Uberla K, Racz P, Steinman RM, Ignatius R
      Vaccine, 2005;23(25):3310-7.
      Species: Primate - Macaca mulatta (Rhesus Macaque)
      Sample Type: Plasma
    79. Increased expression of CXCR3 and CCR5 on memory CD4+ T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis: the role of CXCL10 and CXCL11.
      Authors: Lepej SZ, Rode OD, Jeren T, Vince A, Remenar A, Barsic B
      J. Neuroimmunol., 2005;163(1):128-34.
      Species: Human
      Sample Type: Serum
    80. CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection.
      Authors: Panzer U, Reinking RR, Steinmetz OM, Zahner G, Sudbeck U, Fehr S, Pfalzer B, Schneider A, Thaiss F, Mack M, Conrad S, Huland H, Helmchen U, Stahl RA
      Transplantation, 2004;78(9):1341-50.
      Species: Human
      Sample Type: Urine
    81. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
      Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
      Eur. J. Immunol., 2004;34(4):1164-74.
      Species: Human
      Sample Type: Plasma
    82. Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma.
      Authors: Liu L, Jarjour NN, Busse WW, Kelly EA
      Am. J. Respir. Crit. Care Med., 2004;169(10):1118-24.
      Species: Human
      Sample Type: BALF
    83. Helper T-lymphocyte-related chemokines in healthy newborns.
      Authors: Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TP, Lam CW, Fok TF
      Pediatr. Res., 2003;55(2):334-8.
      Species: Human
      Sample Type: Serum
    84. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
      Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
      J. Leukoc. Biol., 2003;73(5):584-90.
      Species: Human
      Sample Type: CSF
    85. TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
      Authors: Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M
      Eur. J. Immunol., 2002;32(7):2037-45.
      Species: Human
      Sample Type: Cell Culture Supernates
    86. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
      Authors: Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
      Immunity, 2001;14(6):705-14.
      Species: Human
      Sample Type: Cell Culture Supernates
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