Human CXCR4 Biotinylated Antibody Sampler

Name: Human CXCR4 Biotinylated Antibody Sampler
Brand: R&D Systems
SKU: FABSP2B

R&D Systems | Catalog # FABSP2B

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Product Documents

1 vial each of clones 44708, 44716, 44717, and 12G5, biotinylated

Discontinued Product

FABSP2B has been discontinued. View all CXCR4 products.

Product Specifications
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Biotin

Antibody Source

Monoclonal Mouse Clone # 44708, 44716, 44717, 12G5

View all CXCR4 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Applications for Human CXCR4 Biotinylated Antibody Sampler

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

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Formulation, Preparation, and Storage

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: CXCR4

CXCR4, also known as fusin or LESTR, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR4 is 352 amino acids (aa) in length with a predicted molecular weight of 40 kDa. The mouse and rat proteins share 91% aa sequence identity with the human protein. CXCR4 is the chemokine receptor for CXCL12. CXCR4 is a critical regulator of progenitor and stem cell mobilization and recruitment during development and during hematopoiesis. As such, antagonists of CXCR4 can be used to harvest hematopoietic stem/progenitor cells from bone marrow. Significantly, CXCR4 also acts as a co-receptor for HIV and mediates viral entry and infection of T cells. Studies on multiple tumor types implicate the CXCL12:CXCR4 axis in tumor metastasis and angiogenesis.