Neural Stem Cell Differentiation Pathways & Lineage-specific Markers

Click on a cell type below to view a subset of molecules used as markers for the identification of that cell type.

Neural Stem Cells
Neural Stem Cells
Self-Renewal Factors
Self-Renewal Factors
EGF
EGF
ProductsClose
FGF basic
FGF basic
ProductsClose
FGF-10
FGF-10
ProductsClose
Sonic Hedgehog/Shh
Sonic Hedgehog/Shh
Small Molecules for Differentiation
Small Molecules for Differentiation
Neural Progenitor Cells
Neural Progenitor Cells
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
Radial Glial Cells
Radial Glial Cells
Basal/Intermediate
Progenitor Cells
Basal/Intermediate
Progenitor Cells
FGF basic
FGF basic
ProductsClose
PDGF-AA
PDGF-AA
ProductsClose
PDGF-AB
PDGF-AB
ProductsClose
PDGF-BB
PDGF-BB
ProductsClose
Retinoic Acid
Retinoic Acid
Neuron-Restricted
Progenitors
Neuron-Restricted
Progenitors
BDNF
BDNF
ProductsClose
FGF-4
FGF-4
ProductsClose
FGF-8b
FGF-8b
ProductsClose
Sonic Hedgehog/Shh
Sonic Hedgehog/Shh
Dibutyryl-cAMP
Dibutyryl-cAMP
Dopaminergic Neuron
Differentiation Kit
Dopaminergic Neuron
Differentiation Kit
Dopaminergic
Neurons
Dopaminergic
Neurons
BDNF
BDNF
ProductsClose
GDNF
GDNF
ProductsClose
IGF-I
IGF-I
ProductsClose
NT-4
NT-4
ProductsClose
Sonic Hedgehog/Shh
Sonic Hedgehog/Shh
Retinoic Acid
Retinoic Acid
Valproic Acid
Valproic Acid
GABAergic Neurons
GABAergic Neurons
BMP-2
BMP-2
ProductsClose
BMP-4
BMP-4
ProductsClose
FGF-8b
FGF-8b
ProductsClose
Retinoic Acid
Retinoic Acid
Glutamatergic
Neurons
Glutamatergic
Neurons
FGF basic
FGF basic
ProductsClose
Sonic Hedgehog/Shh
Sonic Hedgehog/Shh
Purmorphamine
Purmorphamine
Retinoic Acid
Retinoic Acid
Motor Neuron
Progenitors
Motor Neuron
Progenitors
GDNF
GDNF
ProductsClose
IGF-I
IGF-I
ProductsClose
Motor Neurons
Motor Neurons
CNTF
CNTF
ProductsClose
FGF basic
FGF basic
ProductsClose
PDGF
PDGF
ProductsClose
Thyroid Hormone (T3)
Thyroid Hormone (T3)
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
Glial-Restricted Progenitors
Glial-Restricted Progenitors
EGF
EGF
ProductsClose
FGF basic
FGF basic
ProductsClose
PDGF
PDGF
ProductsClose
Oligodendrocyte-Type 2
Astrocyte (O-2A) Precursors
Oligodendrocyte-Type 2
Astrocyte (O-2A) Precursors
CNTF
CNTF
ProductsClose
IGF-I
IGF-I
ProductsClose
NT-3
NT-3
ProductsClose
PDGF
PDGF
ProductsClose
Thyroid Hormone (T3)
Thyroid Hormone (T3)
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
Oligodendrocyte
Differentiation Kit
Oligodendrocyte
Differentiation Kit
Oligodendrocytes
Oligodendrocytes
CNTF
CNTF
ProductsClose
EGF
EGF
ProductsClose
FGF basic
FGF basic
ProductsClose
PDGF
PDGF
ProductsClose
Type 2 Astrocytes
Type 2 Astrocytes
FGF basic
FGF basic
ProductsClose
PDGF
PDGF
ProductsClose
Type 1 Astrocytes
Type 1 Astrocytes

Overview of Neural Stem Cells & Lineage-specific Markers

Neural stem cells (NSC) are undifferentiated precursor cells defined by their capacity for self-renewal and mulitpotency. During central nervous system development, NSCs proliferate and divide to generate clonally related progeny that differentiate into neurons, astrocytes, oligodendrocytes, and ventricular ependymal cells. The symmetric division of NSCs underlies their ability to self-renew and serves to maintain the NSC population. In contrast, asymmetric mitosis produces one NSC and one neural progenitor cell (NPC), daughter cells with differentiation capacity restricted to neuronal or glial lineages. Asymmetric division generates two NPCs, but does not contribute to maintaining the NSC pool. NSC self-renewal and differentiation is regulated by a precise temporal sequence of growth factor presentation, intracellular signaling, and transcription factor expression. NSCs and their differentiated progeny can be identified by the expression of a unique combination of cell surface markers and transcription factors. Navigate through the pathway above to discover lineage-specific differentiation factors and cell-specific markers for NSCs as well as their terminally differentiated progeny and transitional intermediates. Unique identifiers for each cell can be viewed by clicking on that cell-type within the lineage pathway.

To learn more, please visit our Neural Stem Cell Products Research Area.

Neural Stem Cell Differentiation Pathways & Lineage-specific Markers background image 1Neural Stem Cell Differentiation Pathways & Lineage-specific Markers background image 2Neural Stem Cell Differentiation Pathways & Lineage-specific Markers background image 3Neural Stem Cell Differentiation Pathways & Lineage-specific Markers background image 4Neural Stem Cell Differentiation Pathways & Lineage-specific Markers background image 5