There are three beta‑glucosidases (GBA) in human genome. GBA1 endodes a lysosomal membrane protein that cleaves the beta‑glucosidic linkage of glucosylceramide (1). GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides (2). GBA3 is a cytosolic beta‑glucosidase and is predominantly expressed in liver. GBA3 efficiently hydrolyzes beta‑D‑glucoside and beta‑D‑galactoside, but not any known physiological beta‑glycoside, suggesting that it may be involved in detoxification of plant glycosides (3). GBA3 also has significant neutral glycosylceramidase activity, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (4). At the protein level, GBA3 shows significant homology (>40%) with Klotho protein that is known for its association with aging process (3, 4).
Human Cytosolic beta-Glucosidase/GBA3 Alexa Fluor™ Plus 555‑conjugated Antibody
R&D Systems | Catalog # AF5969AFP555
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications
Immunoprecipitation
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: Cytosolic beta-Glucosidase/GBA3
References
- Tybulewicz, V.L. et al. (1992) Nature 357:407.
- Matern, H. et al. (2001) J. Biol. Chem. 276:37929.
- de Graaf, M. et al. (2001) Biochem. J. 356:907.
- Hayashi, Y. et al. (2007) J. Biol. Chem. 282:30889.
Alternate Names
Gene Symbol
UniProt
Additional Cytosolic beta-Glucosidase/GBA3 Products
Product Documents
Certificate of Analysis
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Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
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- Cellular Response to Hypoxia Protocols
- Immunoprecipitation Protocol
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars