Human Cytosolic beta-Glucosidase/GBA3 Antibody

There are three beta‑glucosidases (GBA) in human genome. GBA1 endodes a lysosomal membrane protein that cleaves the beta‑glucosidic linkage of glucosylceramide (1). GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides (2). GBA3 is a cytosolic beta‑glucosidase and is predominantly expressed in liver. GBA3 efficiently hydrolyzes beta‑D‑glucoside and beta‑D‑galactoside, but not any known physiological beta‑glycoside, suggesting that it may be involved in detoxification of plant glycosides (3). GBA3 also has significant neutral glycosylceramidase activity, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (4). At the protein level, GBA3 shows significant homology (>40%) with Klotho protein that is known for its association with aging process (3, 4).